United and the Reds have won 38 league titles between them and the rivalry between the two clubs cannot be underestimated.
The Red Devils have enjoyed more domestic success over the past two decades but Liverpool fans feel optimistic that the tide is about to change under the stewardship of Jurgen Klopp.
Liverpool will could welcome back Adam Lallana who has recovered from injury but Sheyi Ojo, Joseph Gomez and Mamadou Sakho are all out. Summer arrival Georginio Wijnaldum faces a late fitness test which could see Germany international of Turkish origin return to the starting line-up in central midfield.
United will be without Phil Jones but Jose Mourinho revealed mid-week that Luke Shaw and Henrikh Mkhitaryan have both recovered from injury.
Team captain Wayne Rooney is expected to be left on the bench once again due to being in poor form lately.
PROBABLE LIVERPOOL XI: Karius, Milner, Matip, Lovren, Clyne, Can, Henderson, Coutinho, Mané, Lallana, Firmino
PROBABLE MANCHESTER UNITED XI: Dea Gea, Valencia, Bailly, Smalling, Blind, Herrera, Pogba, Lingaard, Mata, Rashford, Ibrahimovic