The 22 year-old starts in a three man midfield alongside James Milner and club captain Jordan Henderson.
The Germany international is coming off the back of an impressive performance against Arsenal during the week.
Can took 75 touches, made 39 accurate passes and two key passes according to Opta stats. The 22-year-old also contributed defensively with two tackles, three interceptions and an impressive 12 defensive duels won.
The draw saw Liverpool move into 9th point meanwhile Arsenal were able to just about keep onto the number one spot on goal difference after Leicester City beat Tottenham at White Hart Lane.
Liverpool can move up to 6th place with a win over their rivals tomorrow.
Liverpool v Manchester United
Liverpool: Mignolet, Clyne, Toure, Sakho, Moreno, Lucas, Henderson, Can, Milner, Lallana, Firmino.
Subs: Ward, Caulker, Smith, Allen, Teixeira, Ibe, Benteke.
Manchester United: De Gea, Young, Smalling, Blind, Darmian, Schneiderlin, Fellaini, Lingard, Herrera, Martial, Rooney.
Subs: Romero, Borthwick-Jackson, McNair, Varela, Pereira, Mata, Memphis