Newcastle have been in free fall lately, losing four games in a row and dropping into 13th place.
The Reds will be without Mamadou Sakho who has been ruled out for up to four weeks with a hamstring injury.
Liverpool will also be without first-choice defender Martin Skrtel due to suspension, captain Steven Gerrard is also out with suspension.
Liverpool – Newcastle
Referee: L Mason
Kick-Off: 20:00 GMT
Liverpool: Mignolet, Johnson, Can, Lovren, Moreno, Allen, Lucas, Henderson, Ibe, Coutinho, Sterling
Subs: Jones, Toure, Lambert, Manquillo, Borini, Brannagan, Markovic
Manager: Brendan Rodgers
Newcastle United: Krul, R.Taylor, Janmaat, Williamson, Colback, Anita, Abeid, Sissoko, Cabella, Obertan, Perez.
Subs: Elliot, Sterry, Gouffran, Gutierrez, Ameobi, Armstong, Riviere.
Manager: John Carver