Spurs meanwhile have a bigger prize on their minds – the Premier League trophy. Tottenham are just five points behind Leicester City and will close the gap to two with a win.
The north London based side do not however, have a good record against the Reds have having lost four out of their last five Premier League games against them.
Emre Can will make his 84th appearance for Liverpool starting in his now customary role in central midfield.
The 22-year-old did start in the 3-2 loss against England last week but only featured briefly against Italy so fatigue should not be a problem.
Liverpool v Tottenham
Kick-off: 17:30 GMT
Liverpool confirmed starting lineup:
Mignolet; Clyne, Sakho, Moreno; Milner, Henderson, Can; Lallana, Coutinho, Sturridge
Manager: Jurgen Klopp
Tottenham confirmed starting lineup:
Lloris; Walker, Alderweireld, Wimmer, Rose; Dembele, Dier, Son, Eriksen, Alli; Kane
Manager: Mauricio Pochettino