The Black Sea Storm are currently joint first in the league on 10 points alongside Fenerbahçe while Galatasaray trail in 13th place with just five points.
Galatasaray won the league title for a record 20th time last season and also lifted the Turkish Cup.
Denayer made his Galatasaray debut against Atletico Madrid in the Champions League midweek in what was his first career game in the competition.
The 20-year-old had an impressive debut against the La Liga giants making several key blocks – four in total, more than any other player in the game – preventing Atleti from converting two clear goal scoring opportunities.
Denayer has a £30 million release clause according to Galatasaray president Dursun Özbek.
“Denayer is one of the highest value players in Turkey and has a £30 million release clause,” Özbek said speaking on the ‘Sportürk’ program on Habertürk.
The young defender will start at right-back despite being a centre-back replacing Sabri Sarıoğlu who had a poor game midweek.