Bayer Leverkusen take on Barcelona needing a win to stand any chance of booking a Champions League Last 16 spot.
Leverkusen are currently in join fifth place in Group B alongside Roma who take on BATE in the other group game.
Barcelona are already through in first place with 13 points but will be without Arda Turan who is still restricted from playing due to the FIFA transfer ban imposed on the club.
Fellow Turkish international Hakan Çalhanoğlu is almost certain to start for Bayer and has been one of the German giants most in form of players in Europe.
Leverkusen v Barcelona
Leverkusen: Leno; Hilbert, Tah, Toprak, Wendell; Kramer, Kampl; Bellarabi, Mehmedi; Kiessling, Hernández.
Out: Jedvaj (thigh), Bender (ankle)
Barcelona: Ter Stegen; Adriano, Bartra, Vermaelen, Alba; Mascherano, Samper, Rakitić; Messi, Munir, Sandro.
Out: Alves (suspended), Douglas (foot), Rafinha (knee), Mathieu (muscular), Sergi Roberto (ankle), Iniesta (rested), Piqué (rested)