The North London based club are currently third but will have to be careful as the Red Devils could leapfrog the Gunners with a win.
Arsenal will be without Arteta, Welbeck, Debuchy and Oxlade-Chamberlain but Mesut Özil will be available and is set to make his 29th appearance this season.
Manchester United v Arsenal
Stadium: Old Trafford
Referee: M Dean
Kick-Off: 16:00 GMT
Manchester United: De Gea, Valencia, Jones, Smalling, Rojo, Mata, Blind, Herrera, Young, Fellaini, Falcao
Subs: Valdes, Blackett, McNair, Di Maria, Januzaj, Van Persie, Wilson
Manager: Louis Van Gaal
Injured: Rooney, Shaw
Arsenal: Ospina, Bellerin, Mertesacker, Koscielny, Monreal, Coquelin, Cazorla, Ramsey, Ozil, Alexis, Giroud
Subs: Szczesny, Martínez, Chambers, Gibbs, Gabriel, Flamini, Rosicky, Wilshere, Gnabry, Walcott
Manager: Arsene Wenger
Injured: Arteta, Welbeck, Debuchy, Oxlade-Chamberlain