The Gunners are currently third but United could overtake the North London based club with a win.
Arsenal could however, push for a second placed finish with a win against their old rivals.
Mesut Özil is expected to make his 29th appearance for Arsenal this season.
The 26-year-old has been in impressive form since his return from injury in 2015 and Arsenal are undefeated in 16 out of the 20 games he has featured in since the turn of the year.
Manchester United v Arsenal
Stadium: Old Trafford
Referee: M Dean
Kick-Off: 16:00 GMT
Manchester United: De Gea, Valencia, Rojo, Smalling, Blind, Jones, Herrera, Mata, Fellaini, Young, Van Persie
Subs: Valdés, Lindegaard, Vermijl, Amos, Thorpe, Blackett, Lingard, Evans, Januzaj, McNair, Rojo, Wilson, Da Silva, Di María
Doubtful: Da Silva, Evans
Injured: Rooney, Shaw
Arsenal: Ospina, Bellerin, Mertesacker, Koscielny, Monreal, Cazorla, Coquelin, Ramsey, Ozil, Sanchez, Giroud
Subs: Szczesny, Martínez, Chambers, Gibbs, Gabriel, Flamini, Rosicky, Wilshere, Gnabry, Walcott
Injured: Arteta, Welbeck, Debuchy, Oxlade-Chamberlain