Reds boss Jurgen Klopp has decided to start with Emre Can in midfield alongside captain Jordan Henderson.
Klopp has fielded his strongest side with Coutinho, Firminho and Sturrige all in the starting line-up.
Manchester United will be without captain Wayne Rooney who is injured so youngster Rashford will start against upfront with Martial.
Manchester United v Liverpool
Stadium: Old Trafford
Manchester United confirmed starting lineup:
De Gea, Varela, Smalling, Blind, Rojo, Carrick, Fellaini, Lingard, Mata, Martial, Rashford
Subs: Romero, Darmian, Valencia, Williams, Schneiderlin, Schweinsteiger, Memphis
Manager: Louis van Gaal
Liverpool possible confirmed lineup:
Mignolet, Clyne, Lovren, Sakho, Milner, Can, Henderson, Lallana, Coutinho, Firmino, Sturridge.
Subs: Ward, Toure, Smith, Allen, Ibe, Origi, Benteke.
Manager: Jurgen Klopp