Mesut Ozil is expected to start in his favoured number ten role behind striker Olivier Giroud.
City will be without their star defender and captain Vincent Kompany after he suffered a calf injury during the Citizen’s defeat to Real Madrid in the UEFA Champions League.
Ozil has enjoyed an impressive season for the Gunners this season so far. The 27-year-old has recorded 18 assists and with two games to go still has a chance of equalling the Premier League record of 20 set by Thierry Henry.
Manchester City v Arsenal
Kick-Off: 16:00 (GMT)
Stadium: Etihad stadium
Manchester City: Hart; Sagna, Otamendi, Mangala, Clichy; Fernando, Fernandinho; De Bruyne, Toure, Sterling; Aguero
Arsenal: Cech; Bellerin, Mertesacker, Koscielny, Monreal; Ramsey, Coquelin; Alexis, Ozil, Iwobi; Welbeck