The Gunners take on the Red Devils’ hoping to end 10 years of misery at Old Trafford in the Premier League.
Arsenal have not won away to United in 10 years but did end a run of eight league games without a win against United with a 3-0 victory over Arsenal at the Emirates in the first half of the season.
Ozil will start for Arsenal and will be hoping his teammates are not as profligate as they were against Barcelona mid-week.
The Germany international created several goalscoring chances but his teammates were unable to convert. The World Cup winner does still boast the highest assist ratio in the league (17).
Manchester United v Arsenal
Stadium: Old Trafford
Referee: 14:00 GMT
Man United confirmed starting lineup:
De Gea; Varela, Carrick, Blind, Rojo; Schneiderlin, Herrera; Lingard, Mata, Memphis; Rashford.
Subs: Romero, McNair, Riley, Fosu-Mensah, Weir, Januzaj, A.Pereira.
Manager: Van Gaal
Arsenal confirmed starting lineup:
Cech; Bellerin, Koscielny, Gabriel, Monreal; Ramsey, Coquelin; Walcott, Ozil, Sanchez; Welbeck
Manager: Arsene Wenger