Arsenal boss Arsene Wenger has made three changes to the standing lineup with Carl Jenkinson starting at right back, Elneny coming in in place of Granit Xhaka while Aaron Ramsey starts on the wing in place of Alex Iwobi.
Mesut Ozil has retained his place in the starting line-up and will be raring to go after being rested over the international break. Ozil has provided four assists and scored seven goals in 14 apperances for the north London based club this season.
Jose Mourinho’s side find themselves in sixth place with 18 points after 11 games. Arsenal meanwhile are unbeaten in 15 games and are in forth place, two points behind leaders Liverpool
Manchester United v Arsenal
Kick-Off: 12:30 (GMT)
Stadium: Old Trafford
Manchester United: De Gea, Valencia, Jones, Marcus Rojo, Darmian, Carrick, Ander, Mata, Pogba, Martial, Rashford
Arsenal: Cech, Jenkinson, Mustafi, Koscielny, Monreal, Coquelin, Elneny, Ramsey, Ozil, Walcott, Alexis