The Gunners have not won away to United in 10 years but did end a run of eight league games without a win against the Red Devils with a 3-0 victory over Arsenal at the Emirates in the first half of the season.
Ozil created several goalscoring chances but his teammates were unable to convert. The World Cup winner does still boast the highest assist ratio in the league (17).
Manchester United v Arsenal
Stadium: Old Trafford
Referee: 14:00 GMT
Man United possible starting lineup:
De Gea; Varela, Smalling, Blind, Rojo; Herrera, Schneiderlin; Depay, Mata, Lingard; Rashford
Manager: Van Gaal
Arsenal possible starting lineup:
Cech; Bellerin, Koscielny, Mertesacker, Monreal; Ramsey, Coquelin; Walcott, Ozil, Sanchez; Giroud
Manager: Arsene Wenger