Zlatan Ibrahimovic is set to make his unofficial debut for United after joining the club from PSG over the summer.
Anthony Martial, Morgan Schneiderlin, Marouane Fellaini and Matteo Darmian have all been included in the squad after missing the China trip.
United boss Jose Mourinho will be familiar with a few Galatasaray players with one name in particular standing out – Wesley Sneijder.
Sneijder played under the command of Mourinho while at Inter Milan where the duo lifted the UEFA Champions League and Serie A together.
Galatasaray and United have a rich history against each other having played six competitive games which all began with a thrilling 3-3 draw at Old Trafford in the 1993 European Cup second round. The Lions slogan ‘Welcome to Hell’ was coined in Istanbul following a goalless draw which knocked United out on the away goals rule.
Manchester United v Galatasaray
Kick-off: 18: 30 GMT
Manchester United probable line-up: De Gea, Darmian, Smalling, Tuanzebe, Blind, Schneiderlin, Fellaini, Mkhitaryan, Rooney, Martial, Ibrahimovic
Manger: Jose Mourinho
Galatasaray probable line-up: Muslera, Linnes, Chedjou, Hakan Balta, Carole, Hamit Altıntop, Dzemaili, Bruma, Sneijder, Sinan Gümüş, Yasin Öztekin