The Reds have two goal advantage going into the clash and Jurgen Klopp has the luxury of a full strength squad to pick from.
Emre Can is almost certain to start in midfield after an impressive few weeks and he is likely to be joined by captain Jordan Henderson.
Lallana, Coutinho and Firminho are likely to be deployed in an attacking midfield role while Daniel Sturridge is expected to start upfront.
United meanwhile will be without captain Wayne Rooney due to injury but Jesse Lingered returns from suspension.
Manchester United v Liverpool
Stadium: Old Trafford
Manchester United possible starting lineup:
De Gea; Varela, Smalling, Blind, Rojo; Schweinsteiger, Schneiderlin; Mata, Lingard, Depay; Martial
Manager: Louis van Gaal
Liverpool possible starting lineup:
Mignolet; Clyne, Lovren, Sakho, Moreno; Can, Henderson; Lallana, Coutinho, Firmino; Sturridge
Manager: Jurgen Klopp