Red Devils manager Jose Mourinho has decided to start Henrikh Mkhitaryan who was a doubt going into the clash after picking up an injury over the international break. The Portuguese tactician will however, be without Luke Shaw.
Manchester City boss Pep Guardiola meanwhile will be without star striker Sergio Aguero who received a FA ban for violent conduct.
The Argentina international picked up a three-game suspension for an elbow on West Ham’s Winston Reid. Iheanacho will fill in for Aguerro up-front in the Manchester derby.
Guardiola has decided to rest Ilkay Gundogan who has yet to reach full match fitness but fellow Germany international Leroy Sane has been included on the bench.
Manchester United v Manchester City
Stadium: Old Trafford
Kick-Off: 12:30 GMT
Manchester United: De Gea, Valencia, Bailly, Blind, Shaw, Fellaini, Pogba, Mkhitaryan, Rooney (c), Lingard, Ibrahimovic
Subs: Romero, Smalling, Herrera, Mata, Schneiderlin, Martial, Rashford
Manchester City: Bravo, Sagna, Otamendi, Stones, Kolarov, Fernandinho, De Bruyne, Silva (C), Sterling, Nolito, Iheanacho
Subs: Caballero, Fernando, Sane, Zabaleta, Clichy, Navas, A. Garcia