Manchester United will be hoping to turn around their fortunes after a disappointing start to their Europa League campaign.
The Red Devils lost their opening group stage game 1-0 against Dutch giants Feyenoord in the Netherlands.
United captain Wayne Rooney has been left on the bench after being dropped for Saturday’s home win against Leicester City.
United boss Jose Mourinho revealed in his pre-match press conference that Henrikh Mkhitaryan will not feature.
Anthony Martial (concussion) will not start but is on the bench.
Record breaking summer signing Paul Pogba will start in midfield and fellow recent arrival Zlatan Ibrahimovic will get the nod upfront.
Sergio Romero has been given a chance in goal filling in for De Gae and David Mata has kept his place in the side.
United will be without Luke Shaw and Phil Jones who are both injured going into the Zorya clash.
In the other Europa League Group A game Fenerbahce will take on Feyenoord in the Sukru Saracoglu stadium in Istanbul.
Manchester United Confirmed XI: Romero, Fosu-Mensah, Bailly, Smalling, Rojo, Fellaini, Pogba, Lingard, Mata, Rashford, Ibrahimovic
Subs: Johnstone, Carrick, Schneiderlin, Young, Martial, Rooney, Memphis
Zorya: Shevchenko, Kamenyuka, Sivakov, Forster, Sobol, Karavaev, Grechyshkin, Chaykovsky, Petrak, Ljubenovic
