Voetbal Primeur state that an incident during a training game before Netherlands’ 2-1 win over Kazakhstan caused a rift between the two players.
The report claims that Van Persie asked Depay if he thought he was a “big boy”. Depay reportedly replied with: “Do big boys play at Fenerbahce then?”
Van Persie was subsequently left out of the starting line-up which faced Kazakhstan. The Netherlands ended up missing out on Euro 2016.
The 32-year-old striker made the move to the Turkish Super League over the summer after completing his transfer from Manchester United to Fenerbahçe on a three-year deal.
The Dutch star has six goals and on assist in all competitions for the Yellow Canaries this season.
Fenerbahce currently find themselves in second place in the Turkish Super Lig with 34 points in 15 games. The Istanbul Giants take on Gençlerbirliği this weekend in the league.