Manchester City are currently league leaders after beating Newcastle United 6-1 at the City of Manchester stadium.
The Gunners are currently in sixth place on 13 points but a win would take the North London based side into joint second place alongside United.
Arsenal will be without Laurent Koscielny Mikel Arteta and Flamini due to injuries while Ander Herrera and Marcos Rojo are out for the Red Devils.
Gunners star Mesut Özil is expected to start after a dismal performance against Olympiakos in the Champions League. Arsenal lost the game 3-2 but to be fair most the team put on a poor performance.
Arsenal v Manchester United
Kick-Off: 16:00 GMT
Arsenal possible starting lineup: Cech, Bellerin, Mertesacker, Gabriel, Monreal, Coquelin, Cazorla, Ramsey, Ozil, Sanchez, Walcott
Manager: Arsene Wenger
Manchester United possible starting lineup: De Gea, Valencia, Smalling, Blind, Darmian, Schneiderlin, Carrick, Mata, Rooney, Memphis, Martial
Manager: Louis van Gaal