Beşiktaş manager Slaven Bilic has decided not to take Milosevic, İsmail Köybaşı, Tolga Zengin, Cenk Tosun, Uğur Boral and Tomas Sivok to Eskişehir due to injury.
The Black Eagles take on Eskişehirspor at the Atatürk stadium on Sunday 22 February.
Beşiktaş are currently 1st in the Süper Lig but will have to win if they want to secure their place at the top of the table going into the 22nd week.
The Istanbul giants also have a total of seven players on the verge of picking up an automatic suspension for an accumulation of yellow cards ahead of the Eskişehirspor game.
Demba Ba, Oğuzhan Özyakup, Serdar Kurtuluş, Necip Uysal, Gökhan Töre, Veli Kavlak and Ramon Motta will be suspended for the following league game if they pick up a yellow card against EsEs.
The full Beşiktaş squad that travelled to Eskişehir is as follow:
Cenk Gönen, Günay Güvenç, Enes Fidayeo, Ersan Gülüm, Pedro Franco, Atınç Nukan, Serdar Kurtuluş, Ramon Motta, Daniel Opare, Necip Uysal, Veli Kavlak, Atiba Hutchinson, Oğuzhan Özyakup, Tolgay Arslan, Kerim Frei, Gökhan Töre, Olcay Şahan, Jose Sosa, Mustafa Pektemek, Demba Ba