Besiktas take on Napoli hoping to build upon a decent start to their Champions League campaign which has seen them draw away to Benfica and at home agains Dynamo Kiev.
The Black Eagles are on the hunt for their first win but will be in for a very tough test against an in form Napoli at the San Paolo stadium.
Besiktas will be without star midfielder Oguzhan Ozyakup but do not face any other major injuries going into the tie.
The absence of Ozyakup gives Senol Gunes the pretty straight forward decision of starting Anderson Talisca as his central attacking midfielder. The Brazilian has hit the ground running since joining from Benfica and scored the last-gasp equaliser against the Portuguese giants on Match Day One.
Gunes faces a tough decision over whether to give out of form Aboubakar a chance or play Cenk Tosun who despite being the second choice striker has actually been finding the back of the net.
The midfield is likely to see Gokhan Inler and Atiba Hutchinson partner together with Olcay Sahan and Quaresma out wide.
Fabric could replace the mistake prone Tolga Zengin in goal while Marcelo and Tosic are likely to be on centre-back duty. Caner Erkin and Andreas Beck are expected to get the nod as the teams full-backs.
Stadium: San Paolo
Referee: Sergei Karasev
Kick-Off: 19:45 (GMT)
NAPOLI: Pepe Reina, Elseid Hysaj, Raul Albiol, Faouzi Ghoulam, Kalidou Koulibaly, Marek Hamsik, Allan, Jorginho, Jose Callejon, Dries Mertens, Lorenzo Insigne
MANAGER: Maurizio Sarri
BESIKTAS: Fabri, Andreas Beck, Marcelo, Dusko Tosic, Caner Erkin, Olcay Şahan, Gökhan İnler, Atiba Hutchinson, Anderson Talisca, Quaresma, Vincent Aboubakar
MANAGER: Şenol Güneş