Markovic will start on the bench due to lacking match fitness after spending 105 days on the sidelines but he is expected to feature at some stage over the course of the 90 minutes.
The Serbian international has missed a total of 29 games for the Yellow Canaries this season due to a series of injuries.
Markovic is expected to return to Liverpool at the end of the season but Fenerbahce are keen on keeping on the young winger for another season on loan.
Referee: Mete Kalkavan
Kick-Off: 21.15 (Local Time)
Galatasaray confirmed XI: Muslera, Semih, Denayer, Hakan, Carole, Selçuk, Emre, Sinan, Sneijder, Yasin, Podolski.
Subs: Cenk, Bilal, Umut, Donk, Sinan Gümüş, Koray, Olcan.
Manager: J. Olde Riekerink
Subs: Ertuğrul, Kadlec, Gökhan Gönül, Ozan Tufan, Diego, Markovic, Fernandao
Manager: Vitor Pereira