Atletico Madrid take on rivals Real Madrid in the Champions League quarter-final second leg at the Santiago Bernabeu.
The first-leg ended in a goalless draw at the Vicente Calderon stadium last week.
The La Liga champions are unbeaten in their last seven meetings with Real this season however, a draw may not be enough to see them through.
A goalless draw would see the game heading into extra time but a score draw would see the Rojiblancos through.
Turkish international Arda Turan is expected to start for Atleti but Mario Suarez is out suspended and Mandzukic is a doubt due to an ankle injury.
Real Madrid will be without Marcelo (suspended), Modrić (knee), Bale (calf), Benzema (knee).
Real Madrid v Atletico Madrid
Kick Off: 19:45 GMT
Stadium: Santiago Bernabeu
Referee: Felix Brych (GER)
Assistant referee Mark Borsch (GER) , Stefan Lupp (GER)
Additional assistant referee Bastian Dankert (GER) , Marco Fritz (GER)
Fourth official Marco Achmüller (GER)
Madrid: Casillas; Carvajal, Varane, Ramos, Coentrão; Isco, Illarramendi, Kroos, James; Ronaldo, Hernández.
• Out: Marcelo (suspended), Modrić (knee), Bale (calf), Benzema (knee)
Atlético: Oblak; Juanfran, Miranda, Godín, Siqueira; Arda Turan, Gabi, Tiago, Koke; Griezmann, Mandžukić.
• Out: Mario Suárez (suspended)
• Doubtful: Mandžukić (ankle)