German giants Bayer Leverkusen take on Roma at the Stadio Olympic in the Champions League Group E on Match Day 4.
Bayer are currently second in the group three points behind leaders Barcelona meanwhile Roma are last on two points after three games.
Roma will be desperate for a win but a victory for Bayer could almost book them a place in the next round.
Bayer star Hakan Çalhanoğlu is almost certain to start and has been in impressive form this season scoring five and providing four assists in all competitions.
Manchester United sent scouts to watch Çalhanoğlu in the 4-4 draw against Roma in their last Champions League game according to Bild and it would not be a surprise for him to have a number of suitors in the stands today either.
Roma v Leverkusen
Kick-Off: 19:45 GMT
Stadium: Stadio Olimpico
Roma: Szczęsny; Florenzi, Manolas, Rüdiger, Digne; Nainggolan, De Rossi, Pjanić; Gervinho, Džeko, Salah.
Out: Totti (thigh), Keita (thigh)
Doubtful: Florenzi (fatigue)
Leverkusen: Leno; Donati, Tah, Papadopoulos, Wendell; Kampl, Kramer; Mehmedi, Bellarabi; Hernández, Kiessling.
Out: Jedvaj (thigh), Hilbert (knee), Seung-Woo (ankle)
Doubtful: Bender (ankle)