Liverpool need just a point from their Match Day 6 game against Sion at the Stade Tourbillon top the group.
The Reds have already booked a place in the Europa League Round of 32 and Jurgen Klopp will rotate his as a result but Emre Can will start in central midfield having missed the 2-0 defeat against Newcastle United on the weekend due to injury.
The 21-year-old of Turkish origin has one goal and one assist in all competitions for the Reds this season.
Klopp will be without the likes of Coutinho, Gomez, Ings, Sakho and Sturridge to injury.
Sion v Liverpool
Kick-Off: 18:00 GMT
Referee: Michael Koukoulakis (GRE)
Stadium: Stade Tourbillon
Expected Starting Line Ups
Liverpool (4-3-3): Mignolet, Clyne, Toure, Lovren, Smith, Henderson, Milner, Can, Lallana, Firmino, Origi.
Subs: Bogdan, Randall, Skrtel, Rossiter, Brannagan, Coutinho, Benteke.
Manager: Jurgen Klopp
Injuries: Coutinho, Gomez, Ings, Sakho, Sturridge
Sion: Vanins; Jagne, Zverotić, Lacroix, Rufli; Salatic, Edimilson, Mujangi Bia, Kouassi; Carlitos, Assifuah
Manager: Didier Tholot