Skrtel made 21 appearances in the Champions League for Liverpool – including one qualifier. The 31-year-old will be joined by Simon Kjaer and Roman Neustadter as part of a back three.
Kjear, is into his second season at the club while summer signing Gregory van der Wiel also starts at right wing back.
Skrtel joined Fenerbahce on a three-year deal from Liverpool over the summer but despite only being at the club for a few weeks he is expected to lead the defence against Monaco.
Fenerbahce v Monaco
Stadium: Ülker Stadyumu
Referee: Jesus Gil Manzano
Kick-Off: 19:30 GMT
Fenerbahce: Fabiano, Kjaer, Skrtel, Neustadter, Van der Wiel, De Souza, Ozan Tufan, Salih Uçan, Hasan Ali Kaldırım, Emenike, Fernandao
Manager: Vitor Pereira
Monaco: De Sanctis, Raggi, Fabinho, Lemar, Jemerson, Dirar, Bakayoko, Sidibe, Mendy, Radamel Falcao, Valère Germain
Manager: Leonardo Jardim