The Gunners would have extended their winning run to three games should they end up beating the Saints today.
The World Cup winner has been in brilliant form for the Gunners providing 15 assists in 16 games this season.
Özil will match the club record for assists provided in a single season if he sets up another goal tonight.
Southampton v Arsenal
Stadium: St Mary’s Stadium
Southampton: Stekelenburg, Cedric, Fonte, Van Dijk, Bertrand, Clasie, Wanyama; Long, Martina, Mane;,Ward Prowse
Subs: Gazzaniga, Yoshida, Tadic, Romeu, Juanmi, Ramirez, Coulker
Arsenal: Read more at: Cech, Bellerin, Koscielny, Mertesacker, Monreal; Ramsey, Flamini, Walcott, Ozil, Campbell, Giroud
Subs: Ospina, Oxlade-Chamberlain, Iwobi, Gibbs, Gabriel, Adelaide