The Reds will overtake the Saints and move into 7th place with a victory today.
Liverpool boss Jurgen Klopp has dropped Henderson who is nursing an injury and started with Emre Can and Joe Allen in midfield. Another major difference to the side that beat United is Origi starting ahead of Firminho who has been dropped.
Southampton v Liverpool
Stadium: St Mary’s
Kick-Off: 13:00 GMT
Southampton Confirmed Starting XI (4-2-3-1): Forster; Clasie, Fonte, Van Dijk, Soares; Long, Martina; Tadic, Davis, Bertrand; Pelle
Subs: Stekelenburg, Cedric, Yoshida, Mane, Wanyama, Prowse, Juanmi
Manager: Ronald Koeman
Liverpool Predicted Confirmed XI (4-2-3-1): Mignolet, Flanagan, Lovren, Sakho, Clyne, Can, Allen, Lallana, Coutinho, Origi, Sturridge
Subs: Ward, Toure, Benteke, Henderson, Skrtel, Smith, Ojo
Manager: Jurgen Klopp