Galatasaray host the North London based side at the Turk Telekom Arena on December 9 at 19:45 (GMT).
Arsenal are already through to the next round however, were they to beat Galatasaray and if Anderlecht beat Borussia Dortmund the Gunners would clinch first place.
The Gunners beat Galatasaray 4-1 at the Emirates in the first leg and the Lions are yet to win a single game in this seasons competition.
Galatasaray are undefeated in their last five home games against English visitors, winning three and drawing two.
The Lions overall home record against Premier League sides is W3 D4 L2.