The 25-year-old suffered a dislocated knee while still at Borussia Dortmund and is sidelined until the end of the month.
Pep Guardiola will be looking to record his third win in three games this season after defeating both Sunderland and Steaua. Joe Hart is once again expected to be dropped by the former Barcelona boss.
City has a poor record against Stoke City. The Citizens have won just once against Stoke away from home since 2008. Xherdan Shaqiri is a doubtfor the home side as playmaker struggling with ankle problem
Stoke City v Manchester City
Kick-Off: 12:45 (GMT)
Stadium: Britania Stadium
Stoke City probable line up: Given, Pieters, Wollscheid, Shawcross, Bardsley, Whelan, Allen, Imbula, Walters, Arnautovic, Bojan
Man City probable line up: Caballero, Zabaleta, Stones, Kolarov, Clichy, Fernandinho, Silva, Sterling, Nolito, De Bruyne, Aguero