A victory against Spurs would see Arsenal join their rivals on 54 points in joint second place.
Gunners boss Arsene Wenger has several key decisions to make going into the derby. First-choice keeper Petr Cech is out as is defender Laurent Koscielny.
Joel Campbell could get a start after impressing against Swansea – and scoring. Wenger faces a big decision over whether to stick with Olivier Giroud who has not scored in his last 10 games and Alexis Sanchez may get dropped as he has been struggling with form.
Mesut Ozil is almost certain to start and won the Vitality Player of the Month award for the fourth time this season mid-week.
Tottenham v Arsenal
Stadium: White Hart Lane
Kick-Off: 12:45 GMT
Tottenham possible XI: Lloris; Walker, Alderweireld, Wimmer, Rose; Dier, Dembele; Lamela, Alli, Eriksen; Kane.
Arsenal possible XI: Ospina; Bellerin, Mertesacker, Gabriel, Monreal; Coquelin, Ramsey; Campbell, Ozil, Sanchez; Welbeck.
Subs: Arsene Wenger