Brendan Rodgers was sacked following the 1-1 draw against rivals Everton in the Merseyside derby before the international break.
Klopp was appointed as his replacement during the two-week interval and will take charge of his first league game against Spurs.
Can was a regular first-choice starter for Rodgers but was used primarily as a defender last season.
The 21-year-old will however, start in his preferred midfield role in his first game under the stewardship of Klopp.
Tottenham v Liverpool
Stadium: White Hart Lane
Kick-Off: 12:45 GMT
Tottenham confirmed line-up: Hugo Lloris, Walker, Alderweireld, Vertonghen, Davies, Alli, Dembele, Lamela, Eriksen, Chadli, Harry Kane
Liverpool confirmed line-up: Simon Mignolet, Nathaniel Clyne, Martin Skrtel, Dejan Lovren, Alberto Moreno, Emre Can, Lucas Leiva, James Milner, Phillippe Coutinho, Daniel Sturridge, Adam Lallana