Brendan Rodgers was sacked following the 1-1 draw against rivals Everton in the Merseyside derby before the international break.
Klopp was appointed as his replacement during the two-week interval and will take charge of his first league game against Spurs.
Emre Can was a regular first-choice starter for Rodgers and is expected to keep his place in the team under the command of Klopp.
Can was used primarily as a defender last season despite being a central midfielder and it remains to be seen how Klopp will decide to use the Germany international.
Tottenham probable line-up: Hugo Lloris, Walker, Alderweireld, Vertonghen, Davies, Alli, Dembele, Lamela, Eriksen, Chadli, Harry Kane
Liverpool probable line-up: Simon Mignolet, Nathaniel Clyne, Martin Skrtel, Dejan Lovren, Alberto Moreno, Emre Can, Lucas Leiva, James Milner, Phillippe Coutinho, Daniel Sturridge, Adam Lallana