City have a few missing players in Kevin de Bruyne, Vincent Company and Fabian Delth who are injured and Nolito is suspended.
Tottenham meanwhile are missing star striker Harry Kane but Dier, Rose and Sissoko could return to the side after recovering from injury.
Germany international of Turkish origin Ilkay Gundogan is set to fill in for De Bruyne in midfield and is likely to start alongside David Silva and Fernandinho in midfield.
Sergio Aguero is almost certain to start upfront while Sterling and Sane will play out wide.
Janssen is likely to fill in as striker in the absence of Kane with Erikson behind him in a number 10 role and Son as well as Lamela out wide.
Tottenham Probable Line-ups: Lloris, Alderweireld, Vertonghen, Walker, Alli, Dier, Son, Erikson, Lamela, Janssen
Man City Probable Line-ups: Bravo, Otamendi, Stones, Sagna, Clichy, Fernandinho, Silva, Sterling, Sane, Aguero