Başakşehir crashed out of the title race following a 2-2 draw against Fenerbahçe at the Fatih Terim stadium.
Former Galatasaray striker Mehmet Batdal opened the scoring on 53 minutes and bagged a brace just 10 minutes later.
Fenerbahçe looked down and out but Diego scored on 81 minutes to give his side a glimmer of hope.
Any hopes of a fightback looked to have been extinguished when Mehmet Topuz was sent off for stamping on Mossoro.
The Yellow Canaries did however, manage to take another step towards a memorable comeback when Pierre Webo equalised just seven minutes later.
Fenerbahçe pushed on for the winning goal but were hit on a counter attack forcing Bruno Alves into saving the ball off the line with his hand.
Alves was shown a direct red card as was left-back Caner Erkin for dissent and Başakşehir were awarded a penalty.
Başakşehir were awarded a penalty but Batdal missed the chance to score a hat-trick when he sent the ball over the bar.
There was yet more late drama as Webo was sent off for a reckless flying kick incident.
İSTANBUL BAŞAKŞEHİR 2-2 FENERBAHÇE
Stadium: Fatih Terim
Referee: Ali Palabıyık
Başakşehir: Volkan Babacan, Uğur Uçar, Yalçın Ayhan, Epureanu, Alparslan Erdem, Visca, Badji, Mahmut Tekdemir, Doka (min. 74 Enver Cenk Şahin), Mossoro (min. 85 Sedat Ağçay), Mehmet Batdal
Manager: Abdullah Avcı
Fenerbahçe: Volkan Demirel, Mehmet Topuz, Alves, Egemen Korkmaz, Caner Erkin, Mehmet Topal, Emre Belözoğlu (min. 46 Meireles), Kuyt (min. 61 Webo), Diego, Alper Potuk, Sow
Manager: İsmail Kartal
Red Cards: min. 83 Mehmet Topuz, min. 90+2 Alves ve Caner Erkin, min. 90+6 Webo (Fenerbahçe)
Yellow Cards: min. 35 Emre Belözoğlu, min. 68 Egemen Kormaz, min. 69 Alves, min. 73 Caner Erkin, min. 89 Meireles, 90+7 Volkan Demirel (Fenerbahçe), min. 41 Mahmut Tekdemir, min. 84 Mossoro (İstanbul Başakşehir): min. 35 Emre Belözoğlu, min. 68 Egemen Kormaz, min. 69 Alves, min. 73 Caner Erkin, min. 89 Meireles, 90+7 Volkan Demirel (Fenerbahçe), min. 41 Mahmut Tekdemir, min. 84 Mossoro (İstanbul Başakşehir)
Goals: 53′ & 63′ Mehmet Batdal, 81′ Diego, 88′ Webo