Beşiktaş beat Galatasaray 2-1 at the Atatürk Olympic stadium to win their second consecutive big Istanbul derby game.
The Black Eagles had previously failed to win a single derby in their last two seasons under current West Ham boss Slaven Bilic.
Galatasaray open the scoring when Wesley Sneijder capitalised on a goalkeeping error by Günay but Mario Gomez was on hand to rescue his team with a thunderbolt of a shot from outside the box to equalise just a minute later.
Second half substitute Gökhan Töre scored the winner that took Beşiktaş back into first place overtaking their other Istanbul rivals Fenerbahçe in the process.
Gomez has now scored three times in the major Istanbul derbies this season and the Black Eagles have won seven out of the eight games in which he has scored.
The Germany international has an impressive 13 goals in all competitions this season and scored his 42nd goal in UEFA competitions against Sporting Lisbon last Thursday – the fourth highest for a German player.