Barca may be in for a tougher test against fourth placed Villarreal and will be without star midfielder Andres Iniesta who has been left out of the squad after picking up an injury.
Luis Enrique will however, have Arda Turan available and Barca have won all 16 games in which the bearded winger has featured this season.
The MSN – Messi, Suarez, Neymar – are almost certain to start upfront with Rakitic and Busquets starring in midfielder alongside Turan.
Turan could face competition from Roberto in midfield but his experience and fiery attitude could made the Turkish international a more attractive choice in the hostile El Madrigal.
Villarreal v Barcelona
Stadium: El Madrigal
Kick-Off: 15:00 GMT
Barcelona (4-3-3): Bravo; Alves, Piqué, Mascherano, Alba; Busquets, Rakitić, Arda; Messi, Suarez, Neymar
Manager: Luis Enrique
Villarreal (4-4-2): Areola; Mario, Ruiz, Bonera, Bailly; Rukavina, Bruno, Pina, Denis; Cedric, Soldado
Manager: Marcelino García Toral