The Germany international has been a constant feature in Liverpool’s starting XI since Jurgen Klopp’s appointment.
Klopp has deployed Can primarily in midfield whereas the Red’s former manager Brendan Rodgers frequently played the 21-year-old in defence.
Can is expected to start alongside club captain Jordan Henderson and Lucas in Liverpool’s three man midfield.
Liverpool sit in ninth place with 24 points in 16 games in the league and have gone two weeks without a win.
Watford v Liverpool
Kick-Off: 13:30 (GMT)
Stadium: Vicarage Road
Watford confirmed starting line-up: Heurelho Gomes, Nathan Aké, Miguel Britos, Craig Cathcart, Nyom, Etienne Capoue, Almen Abdi, Jurado, Ben Watson, Troy Deeney, Odion Ighalo
Liverpool confirmed starting line-up: Bogdan, Clyne, Skrtel, Sakho, Moreno, Lucas, Henderson, Can, Lallana, Coutinho, Firmino.
Subs: Fulton, Toure, Randall, Allen, Ibe, Origi, Benteke.