Jurgen Klopp is expected to field an experimental side against the Hammers. The last time the Reds took on the West Ham they played out a 0-0 draw.
Liverpool were held to a 2-2 draw against Sunderland on the weekend despite taking a two-goal lead against the Premier League strugglers.
Reds star Emre Can started against the Black Cats and managed to complete the highest number of passes over the weekend.
Can has scored one goal in 30 appearances in all competitions for Liverpool this season. The young midfielder managed to keep his place in the first-team following Jurgen Klopp replacing Brendan Rodgers and now plays in his preferred central midfield role.
West Ham v Liverpool
Kick-Off: 19.45 (GMT)
Stadium: Boleyn Ground
West Ham probable starting line-up: Randolph; O’Brien, Reid, Ogbonna, Cresswell; Obiang, Song; Antonio, Payet, Moses; Valencia.
Liverpool probable starting line-up: Ward; Flanagan, Toure, Caulker, Smith; Stewart, Lucas; Ibe, Ojo; Benteke, Sturridge.