The Gunner’s were eliminated in the Last 16 round last season and will be looking to go at least a step further this term.
World Cup winner is coming off the back of an impressive performance in the 2-0 win over Stoke City on the weekend.
Özil provided Theo Walcott with the opening assist and has now created 76 goalscoring chances in the Premier League in 2015, more than any other player.
Arsenal will be without the injured Danny Welbeck, Tomas Rosicky and Jack Wilshere against the Croatian giants.
Zagreb meanwhile have no new injury concerns and ex Manchester United striker Angelo Henriquez starts.
Dinamo Zagreb v Arsenal
Stadium: Maksimir stadium
Kick-Off: 19:45 GMT
Dinamo Zagreb confirmed starting lineup:
Eduardo, Pinto, Taraval, Sigali, Pivaric, Antolic, Ademi, Machado, Pjaca, Soudani, Fernandes
Arsenal confirmed starting lineup:
Ospina, Debuchy, Koscielny, Gabriel, Gibbs, Arteta, Cazorla, Chamberlain, Ozil, Sanchez, Giroud