The World Cup winner has been rested for the cup replay with an important Premier League game against West Brom looming.
The Gunners are without a win in their last three games in all competitions culminating with a 2-2 draw against Tottenhan in the north London derby.
Arsene Wenger will be without the suspended Francis Coquelin as well as Petr Cech, Alex Oxlade-Chamberlain,Jack Wilshere, Santi Cazorla and Tomas Rosicky due to injury.
Wenger has also decided to drop Alexis Sanchez and Aaron Ramsey who both scored against Tottenham in the north London derby on the weekend.
Hull City v Arsenal
Stadium: KC Stadium
Kick-Off: 20:00 GMT
Hull expected starting XI: Jakupović, Bruce, Davies, Maguire, Odubajo, Elmohamady, Meyler, Huddlestone, Diamé, Powell, Diomandé
Subs: Kuciak, Taylor, Hernandez, Livermore, Aluko, Robertson, Tymon
Arsenal expected starting XI: Ospina, Chambers, Mertesacker, Gabriel, Gibbs, Flamini, Elneny, Walcott, Iwobi, Campbell, Giroud
Subs: Macey, Monreal, Ramsey, Reine-Adelaide, Willock, Ozil, Alexis
Manager: Arsene Wenger